ZIKV-003: Infection with French Polynesian Zika virus during the first pregnancy trimester

2018-02-20

Primary objectives

  • Assess whether fetal development is impacted by maternal infection with French Polynesian Zika virus during the first pregnancy trimester
  • Measure concentration of Zika virus RNA in amniotic fluid and virus transmission to the fetus
  • Pilot methods for studying Zika virus infection during pregnancy

Study design

A single pregnant Indian-origin rhesus macaque (approximately 25-30 days post-conception) will be challenged subcutaneously with 10E4 PFU French Polynesian Zika virus. Natural history of Zika virus will be evaluated as in ZIKV-001. Additionally, we will quantify virus in amniotic fluid at multiple timepoints and monitor fetal development by ultrasound imaging.

Result summary

A pregnant rhesus macaques was infected with Zika virus on March 7, 2016

Participants

  • 827577 challenged with 10E4 PFU Zika virus/H.sapiens-tc/FRA/2013/FrenchPolynesia-01_v1c1
Real-time editorial study commentary

Clinical and Assay Data

Viral challenge stock analysis

Viral RNA quantification

  • Plasma viral loads Chart
  • Pan urine viral loads Chart
  • Oral swab viral loads Chart
  • Amniotic Fluid viral loads Chart

Clinical

Immunology

Ultrasounds Data

Fetectomy Tissues Data | Histopathology

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