ZIKV-002: Infection of three rhesus macaques with Uganda 1947 Zika virus

2018-02-19

Primary objectives

  • Assess the infectivity of a Zika virus isolate from Africa at different doses in rhesus macaques
  • Measure concentration of Zika virus RNA in plasma, urine, CSF, saliva, and feces
  • Determine whether immunity elicited by Zika virus infection protects from subsequent re-infection with genetically heterologous, Asian-lineage Zika viruses

Study design

Three Indian-origin rhesus macaques will be challenged subcutaneously with different doses of African lineage Zika virus (Uganda 1947). For each of the first 10 days, samples will be collected daily for intensive virologic analyses. From days 11-28, samples will be collected 2-3x per week. After 28 days, the animals will be rested for approximately 6 weeks before being re-challenged with 10E4 PFU of French Polynesian Zika virus.

Result summary

This study started Monday, March 7, 2016

Participants

  • 562876 challenged with 10E6 PFU Zika virus/R.macaque-tc/UGA/1947/MR766-3329
  • 405734 challenged with 10E5 PFU Zika virus/R.macaque-tc/UGA/1947/MR766-3329
  • 295022 challenged with 10E4 PFU Zika virus/R.macaque-tc/UGA/1947/MR766-3329

Clinical and Assay Data

Real-time editorial study commentary

Viral challenge stock analysis

Viral RNA quantification

  • Plasma viral loads Chart
  • Pan urine viral loads Chart
  • Cystocentisis viral loads Chart
  • CSF viral loads Chart
  • Oral swab viral loads Chart

Clinical

Immunology

(Note: When more than one plot is available, scroll down to see all plots. Click 'TestId' in the bottom right corner to show/hide specific plots.)