- Determine whether saliva transmission of Zika virus is possible via several mucosal routes.
One animal was challenged with 10e4 PFU of the Asian lineage virus subcutaneously, as in our previous studies. Oral swabs from this donor animal were eluted in saline to use for saliva challenges in two additional animals (ZIKV-017
), with saliva applied to the tonsils. We are sampling daily for up to 10dpi, then weekly through 28dpi. Viral loads will be performed on plasma, saliva oral swabs, urine, and whole blood. Serum will be collected for plaque assays/TCID50 once plasma viremia is detected.
- 756591 challenged with 10E4 PFU Zika virus/H.sapiens-tc/FRA/2013/FrenchPolynesia-01_v1c1
Clinical and Assay Data
Viral RNA quantification
- Plasma viral loads Chart
- Urine viral loads Chart
- Oral swab viral loads Chart
- Neutralizing Antibody Titers