Study Overview 
Investigator: O'Connor and Osorio Grant: NIH P51 to WNPRC and NIH R01 supplement 3R01AI116382-01A1S1 to O'Connor


ZIKV-015 tracks data in 34 datasets over 520 time points. Data is present for 1 Participant.

Study Navigator
Study Navigator

ZIKV-015 

Primary objectives

  • Determine whether saliva transmission of Zika virus is possible via several mucosal routes.

Study design

One animal was challenged with a high dose (10e6 PFU) of the Asian lineage virus via tonsillar challenge to determine if mucosal infection is possible. Animal will be challenged up to 5 times (every 3 days) if not infected after the first challenge. We are sampling daily for up to 11dpi, then weekly through 28dpi. Viral loads will be performed on plasma, saliva oral swabs, urine, and whole blood. Serum will be collected for plaque assays/TCID50 once plasma viremia is detected.

Participants

  • 590870 challenged with 10E6 PFU Zika virus/H.sapiens-tc/FRA/2013/FrenchPolynesia-01_v1c1

Clinical and Assay Data

Viral RNA quantification

  • Plasma viral loads Chart
  • Urine viral loads Chart
  • Oral swab viral loads Chart

Clinical

Immunology

  • Neutralizing Antibody Titers


Plasma Viral Load 

Urine Viral Load 

Oral swab viral load