Study Overview 
Investigator: O'Connor and Osorio Grant: NIH P51 to WNPRC and NIH R01 supplement 3R01AI116382-01A1S1 to O'Connor


ZIKV-013 tracks data in 34 datasets over 472 time points. Data is present for 3 Participants.

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ZIKV--013 

Primary objectives

Determine whether immunity elicited by previous Dengue virus infection affects primary infection with Zika virus

Study design

Three Indian-origin rhesus macaques were previously challenged with 600,000 PFU of DENV3 up to a year ago and all had PRNT results with neutralizing titers. These animals will be challenged subcutaneously with 10e4 French Polynesian Zika virus to determine whether DENV immunity affects Zika virus infection through antibody dependent enhancement (ADE). Samples will be collected daily up to 10dpi, then on days 14, 21, and 28.

Participants

  • 321142 challenged with 10E4 PFU Zika virus/H.sapiens-tc/FRA/2013/FrenchPolynesia-01_v1c1
  • 489988 challenged with 10E4 PFU Zika virus/H.sapiens-tc/FRA/2013/FrenchPolynesia-01_v1c1
  • 850585 challenged with 10E4 PFU Zika virus/H.sapiens-tc/FRA/2013/FrenchPolynesia-01_v1c1

Viral RNA quantification

  • Plasma viral load Chart
  • Urine viral load Chart
  • Oral swab viral load Chart

Clinical Data

Immunology

Neutralizing antibody titers


Plasma Viral Load 

Urine Viral Load 

Oral swab viral load 

Neutralizing Antibody Titers 

DENV Neutralizing Antibody Titers 

DENV and ZIKV neutralizing antibodies prior to ZIKV infection 

 

Neutralizing antibody data looking at the cross-reactivity of DENV and ZIKV prior to ZIKV infection. DENV Data | ZIKV Data

  Attached Files  
   
 ZIKV013_ZIKV_DENV_d0_labkeyids.jpg


DENV and ZIKV neutralizing antibodies post to ZIKV infection 

Neutralizing antibody data looking at the cross-reactivity of DENV and ZIKV 28 day post ZIKV infection. DENV Data | ZIKV Data

  Attached Files  
   
 ZIKV013_ZIKV_DENV3_d28_labkeyids.jpg