Study Overview 
Investigator: O'Connor and Osorio Grant: NIH P51 to WNPRC and NIH R01 supplement 3R01AI116382-01A1S1 to O'Connor


ZIKV-012 tracks data in 34 datasets over 474 time points. Data is present for 2 Participants.

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ZIKV-012 

Primary objectives

  • Determine whether saliva transmission of Zika virus is possible via several mucosal routes.

Study design

Two recipient animals were challenged with donor saliva from ZIKV-011. Saliva was applied to the tonsillar mucosa. Recipient animals were challenged with donor saliva for 8 consecutive days starting on day 3 post-infection of the donor animal. We are sampling daily for up to 18dpi, then weekly through 28dpi. Viral loads will be performed on plasma, saliva oral swabs, urine, and whole blood. Serum will be collected for plaque assays/TCID50 once plasma viremia is detected.

Result summary

Two animals were challenged with donor saliva from drool (ZIKV-011) applied to the tonsils. No viremia was detected in either of the recipient animals.

Participants

  • 373824 challenged with 10E6 PFU Zika virus/H.sapiens-tc/FRA/2013/FrenchPolynesia-01_v1c1
  • 705709 challenged with 10E6 PFU Zika virus/H.sapiens-tc/FRA/2013/FrenchPolynesia-01_v1c1

Clinical and Assay Data

Viral RNA quantification

  • Plasma viral loads Chart
  • Urine viral loads Chart
  • Oral swab viral loads Chart

Clinical

Immunology

  • Neutralizing Antibody Titers


Plasma Viral Load 

Neutralizing Antibody Titers