Study Overview 
Investigator: O'Connor and Osorio Grant: NIH P51 to WNPRC and NIH R01 supplement 3R01AI116382-01A1S1 to O'Connor


ZIKV-011 tracks data in 34 datasets over 519 time points. Data is present for 1 Participant.

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ZIKV-011 

Primary objectives

  • Determine whether saliva transmission of Zika virus is possible via several mucosal routes.

Study design

One animal was challenged with 10e4 PFU of the Asian lineage virus subcutaneously, as in our previous studies. Oral swabs from this donor animal were eluted in saline to use for saliva challenges in two additional animals (ZIKV-012), with saliva applied to the tonsils. We are sampling daily for up to 18dpi, then weekly through 28dpi. Viral loads will be performed on plasma, saliva oral swabs, urine, and whole blood. Serum will be collected for plaque assays/TCID50 once plasma viremia is detected.

Results summary

Animal was inoculated on August 15, 2016 and was successfully infected as in our previous studies after subcutaneous challenge with 10e4 PFU of the Asian lineage virus.

Participants

  • 861138 challenged with 10E4 PFU Zika virus/H.sapiens-tc/FRA/2013/FrenchPolynesia-01_v1c1

Viral RNA quantification

Clinical and Assay Data

Immunology

  • Neutralizing Antibody Titers


Saliva viral load 

Plasma Viral Load 

Oral swab viral load