Study Overview 
Investigator: O'Connor and Osorio Grant: NIH P51 to WNPRC and NIH R01 supplement 3R01AI116382-01A1S1 to O'Connor


ZIKV-010 tracks data in 34 datasets over 465 time points. Data is present for 1 Participant.

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ZIKV-010 

Primary objectives

  • Determine whether saliva transmission of Zika virus is possible via several mucosal routes.

Study design

One animal was challenged with a high dose (10e6 PFU) of the Asian lineage virus via tonsillar challenge to determine if mucosal infection is possible. Animal will be challenged up to 5 times (every 3 days) if not infected after the first challenge. We are sampling daily for up to 18dpi, then weekly through 28dpi. Viral loads will be performed on plasma, saliva oral swabs, urine, and whole blood. Serum will be collected for plaque assays/TCID50 once plasma viremia is detected.

Result summary

One male rhesus macaque was challenged on August 15, 2016 with 10e6 PFU of the Asian lineage virus via tonsillar challenge. Similar to ZIKV-007, this animal had a slight delay in peak viremia following challenge. After peak, viremia resolved to below the limit of detection by day 10. As in ZIKV-007, this suggests that Zika infection is theoretically possible to transmit via a mucosal route.

Participants

  • 511690 challenged with 10E6 PFU Zika virus/H.sapiens-tc/FRA/2013/FrenchPolynesia-01_v1c1

Clinical and Assay Data

Viral RNA quantification

  • Plasma viral loads Chart
  • Urine viral loads Chart
  • Oral swab viral loads Chart

Clinical

Immunology

  • Neutralizing Antibody Titers


Plasma Viral Load 

Oral swab viral load