Study Overview 
Investigator: O'Connor and Osorio Grant: NIH P51 to WNPRC and NIH R01 supplement 3R01AI116382-01A1S1 to O'Connor


ZIKV-009 tracks data in 32 datasets over 475 time points. Data is present for 3 Participants.

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ZIKV-009 

Primary objectives

  • Determine whether saliva transmission of Zika virus is possible via several mucosal routes.

Study design

Three recipient animals were challenged with donor saliva from ZIKV-008. Saliva was applied to either the tonsils, conjunctiva, or intranasal mucosa. Recipient animals were challenged with donor saliva for 8 consecutive days starting on day 3 post-infection of the donor animal. We are sampling daily for up to 18dpi, then weekly through 28dpi. Viral loads will be performed on plasma, saliva oral swabs, urine, and whole blood. Serum will be collected for plaque assays/TCID50 once plasma viremia is detected.

Result summary

Three animals were challenged on July 23, 2016 with donor saliva from oral swabs eluted in viral transport medium (ZIKV-011) applied to the tonsils, conjunctiva, or intranasal mucosa. Animal 678776 was challenged via tonsils, and a very low level blip was detected on day 2. A retest of this timepoint was negative for viral RNA. Additionally, the animal did not seroconvert, so it is unlikely that the animal was ever infected. No viremia was detected in the other recipient animals.

Participants

Clinical and Assay Data

Viral RNA quantification

  • Plasma viral loads Chart
  • Pan urine viral loads Chart
  • Oral swab virus load Chart

Clinical

Immunology

  • Neutralizing Antibody Titers


Plasma Viral Load 

Neutralizing Antibody Titers