Assess whether fetal development is impacted by maternal infection with Asian lineage Zika virus during the first pregnancy trimester
Measure concentration of Zika virus RNA in amniotic fluid and virus transmission to the fetus
Pilot methods for studying Zika virus infection during pregnancy
A single pregnant rhesus macaque will be challenged subcutaneously with 10E4 PFU Asian lineage Zika virus. We will quantify virus in amniotic fluid at multiple timepoints and monitor fetal development by ultrasound imaging.
660875 challenged with 10E4 PFU Asian lineage Zika virus