Study Overview 
Investigator: O'Connor and Osorio Grant: NIH P51 to WNPRC and NIH R01 supplement 3R01AI116382-01A1S1 to O'Connor


ZIKV-005 tracks data in 34 datasets over 558 time points. Data is present for 2 Participants.

Study Navigator
Study Navigator

ZIKV-005: Infection with Asian lineage Zika virus during the first pregnancy trimester 

Primary objectives

  • Assess whether fetal development is impacted by maternal infection with Asian lineage Zika virus during the first pregnancy trimester
  • Measure concentration of Zika virus RNA in amniotic fluid and virus transmission to the fetus
  • Pilot methods for studying Zika virus infection during pregnancy

Study design

A single pregnant rhesus macaque will be challenged subcutaneously with 10E4 PFU Asian lineage Zika virus. We will quantify virus in amniotic fluid at multiple timepoints and monitor fetal development by ultrasound imaging.

Participants

  • 660875 challenged with 10E4 PFU Asian lineage Zika virus

Clinical and Assay Data

Viral RNA quantification

  • Plasma viral loads Chart
  • Pan urine viral loads Chart
  • Oral swab viral loads Chart
  • Amniotic fluid viral loads: Chart

Clinical

Immunology

Ultrasounds Data

Fetectomy Tissues Data | Histopathology


Ultrasounds 
Grid ViewsReportsChartsExportPrintPaging
Participant ID
Date
Comments
File Name
Days Post Gestation
Days Post Challenge
6608752016-03-25day -33.25.16_660875_d-3_placenta_and_yolk_sac.jpg28.0-3.0
6608752016-03-25day - 33.25.16_660875_d-3.jpg28.0-3.0
6608752016-03-28day 0 post infection3.28.16_660875_d0.jpg31.00.0
6608752016-04-01 4.1.16_660875_d4.jpg35.04.0
6608752016-04-04 660875_4.4.16_d7_placenta.jpg38.07.0
6608752016-04-04 660875_4.4.16_d7.jpg38.07.0
6608752016-04-08 4.8.16_660875_d11.jpg42.011.0
6608752016-04-08 4.8.16_660875_d11_placenta.jpg42.011.0
6608752016-04-12 4.12.16_660875_d15_fetal_brain.jpg46.015.0
6608752016-04-12 4.12.16_660875_d15_fetal_length.jpg46.015.0
6608752016-04-12 4.12.16_660875_d15_heart_rate.jpg46.015.0
6608752016-04-12 4.12.16_660875_d15.jpg46.015.0
6608752016-04-19 ZIKV005_4.19.16_BPD-HC.jpg53.022.0
6608752016-04-19FetusZIKV005_4.19.16_fetus.jpg53.022.0
6608752016-04-19HeartbeatZIKV005_4.19.16_heartbeat.jpg53.022.0
6608752016-04-19Femur LengthZIKV005_4.19.16_femur_length.jpg53.022.0
6608752016-04-19PlacentaZIKV005_4.19.16_placenta.jpg53.022.0
6608752016-04-19SummaryZIKV005_4.19.16_summary.jpg53.022.0
6608752016-04-26HeartbeatZIKV005_4.26.16_heartbeat.jpg60.029.0
6608752016-04-26PlacentaZIKV005_4.26.16_placenta.jpg60.029.0
6608752016-04-26VentricleZIKV005_4.26.16_Ventricle.jpg60.029.0
6608752016-04-26HC-BPDZIKV005_4.26.16_HC-BPD.jpg60.029.0
6608752016-04-26SummaryZIKV005_4.26.16_summary.jpg60.029.0
6608752016-04-26CerebellumZIKV005_4.26.16_Cerebellum.jpg60.029.0
6608752016-04-26Femur LengthZIKV005_4.26.16_femur_length.jpg60.029.0
6608752016-05-03Femur LengthZIKV005_5.3.16_femur_length.jpg67.036.0
6608752016-05-03SummaryZIKV005_5.3.16_summary.jpg67.036.0
6608752016-05-03CerebellumZIKV005_5.3.16_cerebellum.jpg67.036.0
6608752016-05-03HC-BPDZIKV005_5.3.16_HC-BPD.jpg67.036.0
6608752016-05-03PlacentaZIKV005_5.3.16_placenta.jpg67.036.0
6608752016-05-03VentricleZIKV005_5.3.16_Ventricle.jpg67.036.0
6608752016-05-10HeartbeatZIKV_005_5.10.16_IM-0001-0001.jpg74.043.0
6608752016-05-10Femur LengthZIKV_005_5.10.16_IM-0001-0009.jpg74.043.0
6608752016-05-10BPD/HCZIKV_005_5.10.16_IM-0001-0013.jpg74.043.0
6608752016-05-10Cisterna magnaZIKV_005_5.10.16_IM-0001-0017.jpg74.043.0
6608752016-05-17SummaryZIKV_005_660875_IM-0001-0011.jpg81.050.0
6608752016-05-17HeartbeatZIKV_005_660875_IM-0001-0009.jpg81.050.0
6608752016-05-17PlacentaZIKV_005_660875_IM-0001-0008.jpg81.050.0
6608752016-05-17FemurZIKV_005_660875_IM-0001-0006.jpg81.050.0
6608752016-05-17BPD/HCZIKV_005_660875_IM-0001-0001.jpg81.050.0
6608752016-05-24BPD/HCZIKV_005_5_24_2016_BPD_HC_IM-0001-0001.jpg88.057.0
6608752016-05-24Femur lengthZIKV_005_5_24_2016_FL_IM-0001-0003.jpg88.057.0
6608752016-05-24HeartrateZIKV_005_5_24_2016_Heartrate_IM-0001-0004.jpg88.057.0
6608752016-06-07Heart RateIM-0001-0001_ZIKV_005_HeartRate.jpg102.071.0
6608752016-06-07FLIM-0001-0003_ZIKV_005_FL.jpg102.071.0
6608752016-06-07BPD/HCIM-0001-0011_ZIKV_005_BPD_HC.jpg102.071.0
6608752016-06-07SummaryIM-0001-0013_ZIKV_005_Summary.jpg102.071.0
6608752016-06-14BPD/HCIM-0001-0004_ZIKV_005_6_14_BPD_HC.jpg109.078.0
6608752016-06-14Heart RateIM-0001-0006_ZIKV_005_6_14_HeartRate.jpg109.078.0
6608752016-06-14SummaryIM-0001-0028_ZIKV_005_6_14_summary.jpg109.078.0
6608752016-06-14FLIM-0001-0010_ZIKV_005_6_14_FL.jpg109.078.0
6608752016-06-14PlacentaIM-0001-0012_ZIKV_005_6_14_placenta.jpg109.078.0
6608752016-06-21Heart RateIM-0001-0001_ZIKV_005_6_21_HeartRate.jpg116.085.0
6608752016-06-21FLIM-0001-0005_ZIKV_005_6_21_FL.jpg116.085.0
6608752016-06-21PlacentaIM-0001-0008_ZIKV_005_6_21_placenta.jpg116.085.0
6608752016-06-21BPD/HCIM-0001-0011_ZIKV_005_6_21_BPD_HC.jpg116.085.0
6608752016-07-01PlacentaIM-0001-0020_ZIKV_005_7_1_2016_placenta.jpg126.095.0
6608752016-07-01SummaryIM-0001-0022_ZIKV_005_7_1_2016.jpg126.095.0
6608752016-07-01BPD_HCIM-0001-0005_ZIKV_005_7_1_2016_BPD_HC.jpg126.095.0
6608752016-07-01Heart RateIM-0001-0013_ZIKV_005_7_1_2016_Heartrate.jpg126.095.0
6608752016-07-01FLIM-0001-0017_ZIKV_005_7_1_2016_FL.jpg126.095.0
6608752016-07-12Heart RateIM-0001-0001_ZIKV_005_HeartRate_7_12_2016.jpg137.0106.0
6608752016-07-12HCIM-0001-0006_ZIKV_005_HC_7_12_2016.jpg137.0106.0
6608752016-07-12BPDIM-0001-0015_ZIKV_005_BPD_7_12_2016.jpg137.0106.0
6608752016-07-12SummaryIM-0001-0020_ZIKV_005_summary_7_12_2016.jpg137.0106.0
6608752016-07-19BPD_HCIM-0001-0003_ZIKV_005_BPD_HC_7_19_2016.jpg144.0113.0
6608752016-07-19Heart RateIM-0001-0004_ZIKV_005_HeartRate_7_19_2016.jpg144.0113.0
6608752016-07-19FLIM-0001-0008_ZIKV_005_FL_7_19_2016.jpg144.0113.0
6608752016-07-19placentaIM-0001-0013_ZIKV_005_placenta_7_19_2016.jpg144.0113.0
6608752016-07-19SummaryIM-0001-0014_ZIKV_005_summary_7_19_2016.jpg144.0113.0

Key data: plasma viral loads 

Neutralizing Antibody Titers 

Neutralizing antibody data post ZIKV infection 

Neutralizing antibody data post ZIKV infection. Data



  Attached Files  
   
 ZIKV-005_28DPI_nAb_graph.jpg


Messages 
Showing: all messages
Re-breeding follow up
lgomes 2017-08-22
660875 participant: birth on 7-21-2017 by c-section, 10 days overdue. Participant did not take infant back but it was adopted by another animal
view message