|ZIKV infection in dengue-exposed macaques at Caribbean Primate Research Center||mmohns||2016-09-02|
Researchers at CPRC in Puerto Rico have shared preliminary data online, challenging animals with pre-existing DENV immunity (DENV-1 and DENV-2) with ZIKV. Secondary ZIKV infection does not appear to support evidence of antibody-dependent enhancement (ADE) in vivo using the rhesus macaque model.
Data can be found here: http://nprcresearch.org/primate/hot-topics/CPRC-Zika-Virus-Research-Page.pdf
On the heels of the work at CPRC, our group will be starting our next set of Zika studies next Tuesday, infecting 3 rhesus macaques with pre-existing immunity to serotype-3 of DENV. Results will be posted as soon as possible here on our web portal.